Osteoarthritis (OA) of the knee is one of the commonest problems faced by ageing adults and in order to alleviate the pain and morbidity associated with OA, a variety of non-surgical treatment modalities ranging from oral chondroprotectives, intra-articular steroids to viscosupplements have been tried by pain physicians and orthopaedicians worldwide.
Platelet-rich plasma (PRP) is evolving into a promising solution for various orthopaedic conditions like tendinopathies, non-union and arthritis of knee. The success of PRP in treating sports injuries in several high-profile sportsmen has contributed to the hype surrounding the PRP therapy, leading to increasing use of PRP for treating OA knees over the last seven years.
Positive results have been uniformly observed by various researchers for platelet-rich plasma (PRP) in early osteoarthritis (OA) knee in the past few years. PRP has clearly demonstrated its supremacy in comparison to hyaluronic acid (HA) and placebo in various clinical trials and is undoubtedly the best option available for symptomatic treatment in early OA. The release of growth factors from PRP occurs immediately and lasts for around three weeks and the clinical effect tends to wane down by the end of the year. Prolonged and sustained release of growth factors from platelets could possibly help in much better biological healing and sustained clinical effects.