Adynamic Bone Syndrome

Bisphosphonates (BP) are a commonly prescribed class of drugs for the prevention of osteoporosis-related fractures. However, paradoxically, they have been recently linked to fractures in the shaft of the femur. These fractures have been termed ‘atypical’ fractures’  There are scant reports in radiology literature on these atypical fractures. In fact, since many physicians including radiologists are […]


Denosumab is a fully human monoclonal antibody for the treatment of osteoporosis, treatment induced bone loss, bone metastases, rheumatoid arthritis, multiple myeloma and giant cell tumor of bone. Denosumab is designed to target RANKL (RANK ligand), a protein that acts as the primary signal to promote bone removal. In many bone loss conditions, RANKL overwhelms […]